TB-500
TB-500 is a synthetic analog of thymosin beta-4, a naturally occurring 43-amino acid peptide present in nearly all mammalian cells. It has been studied in various animal models for its role in cell migration, tissue repair, and anti-inflammatory processes.
Molecular Information
Research Summary
Thymosin beta-4 and its synthetic fragment TB-500 have been the subject of extensive research in animal models and cell culture systems. The peptide has demonstrated notable effects on wound healing, cardiac repair, and neurological recovery in preclinical studies. Its primary mechanism involves promoting cell migration through interaction with actin, a key structural protein in cells. Research has shown that TB-500 can upregulate cellular receptors involved in tissue repair pathways and modulate inflammatory responses.
Mechanism of Action
TB-500 functions primarily through its interaction with G-actin (globular actin), promoting actin polymerization and cell migration. It upregulates the expression of actin and other healing-related proteins. Research suggests it also modulates inflammatory pathways, reduces oxidative stress, and promotes angiogenesis through VEGF-related mechanisms.
Published Animal Studies
- [1]Equine studies demonstrated improved cardiac function following induced cardiac injury with TB-500 administration (Smart et al., 2007)
- [2]Rodent models showed accelerated dermal wound healing with enhanced re-epithelialization and collagen deposition (Malinda et al., 1999)
- [3]Studies in mice demonstrated neuroprotective effects and improved functional recovery following experimental stroke (Morris et al., 2010)
- [4]Rat studies showed reduced inflammatory markers and improved tissue repair in corneal injury models (Sosne et al., 2002)
In-Vitro Research
- •Endothelial cell cultures demonstrated enhanced migration and tube formation indicating pro-angiogenic properties
- •Keratinocyte studies showed increased cell migration and proliferation in scratch wound assays
- •Cardiac myocyte cultures demonstrated enhanced survival under oxidative stress conditions
Research Applications
Vendor Availability & Pricing
Prices as of March 2026 — for research use only
| Vendor | Size | Price |
|---|---|---|
| Ascension Peptides | 5mg | $44.99 |
| Swiss Chems | 5mg | $42.95 |
| Core Peptides | 5mg | $46.99 |
| Limitless Biotech | 5mg | $48.99 |
| Amino Asylum | 5mg | $27.99 |
| Bioinfinity | 5mg | $39.99 |
References
- 1.Goldstein AL, et al. "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues." Trends Mol Med. 2005;11(9):421-429.
- 2.Smart N, et al. "Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization." Nature. 2007;445(7124):177-182.
Storage & Handling
- Storage
- Store lyophilized peptide at -20C. Reconstituted solution stable at 4C for up to 10 days. Avoid repeated freeze-thaw cycles.
- Solubility
- Soluble in sterile water or bacteriostatic water. Recommended concentration: 2-5 mg/mL.
- Appearance
- White lyophilized powder
Quick Facts
- Category
- Healing Peptides
- Available From
- 6 verified vendors
- Price Range
- $44.99 - $39.99
- Animal Studies
- 4 cited