CJC-1295
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) with 30 amino acids. It is available in two forms: with and without Drug Affinity Complex (DAC). It has been studied in animal models for its effects on pulsatile growth hormone release.
Molecular Information
Research Summary
CJC-1295 is a modified GHRH analog designed for increased stability and extended half-life compared to native GHRH. The version with DAC (Drug Affinity Complex) utilizes a maleimido derivative of lysine that binds to circulating albumin, further extending its biological activity. Research in animal models has demonstrated significant and sustained elevations in growth hormone and IGF-1 levels. The non-DAC version (also known as Modified GRF 1-29) maintains the pulsatile release pattern more closely resembling physiological GH secretion.
Mechanism of Action
CJC-1295 binds to GHRH receptors on anterior pituitary somatotroph cells, activating cAMP/PKA signaling cascades that stimulate growth hormone synthesis and release. The DAC modification allows albumin binding, extending plasma half-life from minutes to days. It preserves the pulsatile pattern of GH release when used in conjunction with GH secretagogues.
Published Animal Studies
- [1]Studies in animal models demonstrated sustained elevation of GH levels for 6-8 days following single administration of DAC-modified CJC-1295 (Jetté et al., 2005)
- [2]Rodent studies showed increased IGF-1 levels and enhanced growth parameters with chronic administration
- [3]Primate research demonstrated dose-dependent GH release with preservation of pulsatile secretion pattern
- [4]Combination studies with GHRP-type peptides in animal models showed synergistic effects on GH release (Bowers et al., 1990)
In-Vitro Research
- •Pituitary cell cultures demonstrated receptor binding affinity and cAMP activation comparable to native GHRH
- •Stability studies showed dramatically increased resistance to DPP-IV enzymatic degradation
- •Albumin binding assays confirmed high-affinity association of DAC-modified CJC-1295 with serum albumin
Research Applications
Vendor Availability & Pricing
Prices as of March 2026 — for research use only
| Vendor | Size | Price |
|---|---|---|
| Ascension Peptides | 2mg | $32.99 |
| Swiss Chems | 2mg | $34.95 |
| Core Peptides | 2mg | $35.99 |
| Limitless Biotech | 2mg | $36.99 |
| Sports Technology Labs | 2mg | $39.99 |
| Amino Asylum | 2mg | $19.99 |
| Bioinfinity | 2mg | $29.99 |
References
- 1.Jetté L, et al. "hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats." Peptides. 2005;26(5):827-834.
- 2.Bowers CY, et al. "On the actions of growth hormone-releasing hexapeptide, GHRP." Endocrinology. 1990;126(6):2940-2946.
Storage & Handling
- Storage
- Store lyophilized peptide at -20C. Reconstituted solution stable at 4C for up to 14 days. Protect from light.
- Solubility
- Soluble in sterile water and bacteriostatic water. Recommended concentration: 1-2 mg/mL.
- Appearance
- White lyophilized powder
Quick Facts
- Category
- GH Secretagogues
- Available From
- 7 verified vendors
- Price Range
- $32.99 - $29.99
- Animal Studies
- 4 cited